ALVIN J. CUMMINS, M.D., F.A.C.P.
Several proteolytic enzymes are known to exist in the blood and urine, and one of the urinary enzymes—uropepsin—has received much attention and study since Bucher's review of the subject in 1947.1 Available evidence indicates that the chief cells of the gastric glands secrete pepsinogen both into the gastric lumen and into the blood in a ratio of about 99:1.2 In the stomach the enzyme precursor is activated to pepsin by hydrochloric acid, while from the blood stream it is excreted in the urine, where it can be assayed at an acid pH as uropepsin. Urinary excretion of uropepsin has
CUMMINS AJ. UROPEPSIN EXCRETION IN THE DIFFERENTIAL DIAGNOSIS OF GASTROINTESTINAL BLEEDING12. Ann Intern Med. ;52:1213–1220. doi: 10.7326/0003-4819-52-6-1213
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Published: Ann Intern Med. 1960;52(6):1213-1220.
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