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Of the many local anesthetic agents available, not any in recent years has received the general acceptance by the medical profession as has Xylocaine. Since its introduction more than a decade ago, it has become an active competitor of the long established procaine hydrochloride.
This treatise gives the historical background leading to the synthesis of Xylocaine and its early clinical trials. Another section of the book is concerned with the mechanism of action of local anesthetics at a cellular level. Pharmacologic procedures for the evaluation of local anesthetics are discussed and their relative merits delineated.
The complete pharmacologic profile of
Xylocaine: The Pharmacological Basis of Its Clinical Use.. Ann Intern Med. 1960;53:240–241. doi: 10.7326/0003-4819-53-1-240_2
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Published: Ann Intern Med. 1960;53(1):240-241.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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