NEMAT O. BORHANI, M.D.
The synthesis of chlorothiazide by Novello and Sprague1 and the discovery of its favorable saluretic action2, 18, 19 introduced a unique type of pharmaceutic agent to the management of cardiovascular diseases. Chlorothiazide (Diuril), a heterocyclic sulfonamyl compound (figure 1A) is an orally effective diuretic, useful in the treatment of congestive heart failure and other edematous conditions. In addition, this drug has some antihypertensive properties, and usually augments the antihypertensive activity of sympathetic depressor agents. It has been claimed that chlorothiazide, by virtue of its activity as a carbonic anhydrase inhibitor, induces natruresis and kaluresis, and causes the excretion of
BORHANI NO. CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE: A COMPARATIVE STUDY OF THEIR HYPOTENSIVE, SALURETIC AND HYPERURICEMIC ACTION12. Ann Intern Med. ;53:342–358. doi: 10.7326/0003-4819-53-2-342
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Published: Ann Intern Med. 1960;53(2):342-358.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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