RUBÉN LISKER, M.D.; ARNOLDO NOGUERÓN, M.D.; LUIS SÁNCHEZ-MEDAL, M.D.
The Ehlers-Danlos syndrome, fully described in a recent monograph by McKusick,1 is a rare, congenital, hereditary disorder of the connective tissue with clear-cut clinical manifestations. Abnormal bleeding in this syndrome occurs frequently,2, 3 and in some patients the hemorrhagic condition may be the prominent abnormality; Samuel et al.4 reported a 32 year old female who gave a history of vaginal, rectal, nasal and cutaneous bleeding. The prominence of the bleeding in some cases led McKusick to state that this syndrome "must be included in the differential diagnosis of familial hemophilia-like states." The consensus regarding the physiopathology of the hemorrhagic
LISKER R, NOGUERÓN A, SÁNCHEZ-MEDAL L. PLASMA THROMBOPLASTIN COMPONENT DEFICIENCY IN THE EHLERS-DANLOS SYNDROME(PLASMA THROMBOPLASTIN COMPONENT DEFICIENCY IN THE EHLERS-DANLOS SYNDROME*). Ann Intern Med. 1960;53:388–395. doi: 10.7326/0003-4819-53-2-388
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Published: Ann Intern Med. 1960;53(2):388-395.
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