MICHAEL J. CARVER, Ph.D.; JOHN G. FREEMAN, M.D.; JACKSON A. SMITH, M.D., F.A.C.P.
The role of cholesterol in the etiology and pathogenesis of atherosclerosis is not clearly understood; nevertheless, an association between hypercholesterolemia and atherosclerosis most probably exists, and has prompted continual study of methods of decreasing the level of serum cholesterol.
The findings of Blohm et al. that Triparanol4 produced a cholesterol-lowering effect on rats, and that the effect was the result of an inhibition of cholesterol biosynthesis, were met with interest by investigators. It was further established by Blohm et al. that the inhibition noted was specific for cholesterol.2 Avigan et al.1 indicate that the principal site of action of Triparanol
CARVER MJ, FREEMAN JG, SMITH JA. EVALUATION OF A CHOLESTEROL-SYNTHESIS INHIBITOR (TRIPARANOL)1. Ann Intern Med. ;53:462–467. doi: 10.7326/0003-4819-53-3-462
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Published: Ann Intern Med. 1960;53(3):462-467.
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