M. J. MURRAY, M.D., M.R.C.P.; A. P. THAL, M.D.
The discovery of circulating antibodies to thyroid tissue and thyroglobulin1 led us to believe that iso-antibodies to pancreas might be present in chronic pancreatitis. Experimental studies, which included the production of chronic pancreatitis in animals and sensitization of animals to injected pancreatic extracts, clearly showed that antibodies to isologous pancreas were present in the sera of these animals.2 We were then able to show in a preliminary study that the sera of patients with chronic pancreatic disease and carcinoma of the pancreas contained iso-antibodies specific to human pancreas.2 Auto-antibodies to human pancreas have also been detected.3 The present study is
MURRAY MJ, THAL AP. THE CLINICAL SIGNIFICANCE OF CIRCULATING PANCREATIC ANTIBODIES(THE CLINICAL SIGNIFICANCE OF CIRCULATING PANCREATIC ANTIBODIES*†)(THE CLINICAL SIGNIFICANCE OF CIRCULATING PANCREATIC ANTIBODIES*†). Ann Intern Med. 1960;53:548–555. doi: 10.7326/0003-4819-53-3-548
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Published: Ann Intern Med. 1960;53(3):548-555.
Gastroenterology/Hepatology, Pancreatic Disease.
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