ROBERT R. MONTGOMERY, M.D.; MAGNUS OLAFSSON, M.D.
The Waterhouse-Friderichsen syndrome typically appears early in the course of severe meningococcic infection, and usually leads swiftly to death. It is characterized by shock, prostration, purpura, and massive hemorrhage into the adrenal glands. Until the advent of sulfonamides, antibiotics and, later, adrenal corticosteroids, it was usually fatal; indeed, if a patient survived, the accuracy of the diagnosis was questioned.
Since its initial description and later clinical definition, it had been reported as occurring in the course of various other infectious diseases. As far as we can determine after an extensive review of the literature, the following case is the first
MONTGOMERY RR, OLAFSSON M. WATERHOUSE-FRIDERICHSEN SYNDROME IN VARICELLA1. Ann Intern Med. 1960;53:576–579. doi: 10.7326/0003-4819-53-3-576
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Published: Ann Intern Med. 1960;53(3):576-579.
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