JOHN H. FRENSTER, M.D.
High-output failure in man has been described both for cardiac blood propulsion1 and for bone marrow erythropoiesis,2 but it also occurs in a wide variety of processes in other organs. It seems implicit in all descriptions of "relative failure" or "relative insufficiency" of the function of an organ.2 The usual response of an organ process when it remains subjected to increased loads is a secondary increase in the capacity to perform the affected function. Such functional hypertrophy has limits, beyond which the increased capacity becomes inadequate for the increasing load. At this point, failure of the function becomes evident
FRENSTER JH. LIMITS TO FUNCTIONAL HYPERTROPHY IN HIGH-OUTPUT FAILURE1. Ann Intern Med. 1960;53:647–655. doi: 10.7326/0003-4819-53-4-647
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Published: Ann Intern Med. 1960;53(4):647-655.
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