W. B. SPAULDING, M.D., F.R.C.P. (C)
Hereditary episodic edema is a rare disease, manifested by recurring attacks of spreading edema which appear rapidly, last only a few days, and leave the patient healthy between episodes. The hereditary pattern is that of a dominant genetic abnormality. The edema may involve the skin or the wall of the mouth, pharynx, larynx or gastrointestinal tract. Edema of the larynx constitutes a grave emergency which may cause death. The clinical features in two families studied personally and in others reported in the literature have previously been reviewed in detail.1
Although knowledge of the clinical manifestations, heredity and prognosis is adequate,
SPAULDING WB. METHYLTESTOSTERONE THERAPY FOR HEREDITARY EPISODIC EDEMA (HEREDITARY ANGIONEUROTIC EDEMA)1. Ann Intern Med. ;53:739–745. doi: 10.7326/0003-4819-53-4-739
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Published: Ann Intern Med. 1960;53(4):739-745.
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