WU-HAO TU, M.D.; CARROLL C. JONES, M.D.; MAX S. ALLEN, M.D., F.A.C.P.
The effects of potassium depletion on the structure and function of the kidneys have probably been observed for at least 40 years. In 1919 Jaffé and Sternberg1 described vacuolar degeneration of the renal tubules in patients who died of dysentery. These observers suggested that the lesion was a distinct pathologic entity, perhaps associated with intestinal disease. Deficiency of potassium as a cause of such renal lesions was suggested by Perkins et al.2 and by Luft et al.3 The subject has recently been well reviewed by Relman and Schwartz,4, 5, 6 who confirmed the etiology and pathogenesis of the lesion by
TU W, JONES CC, ALLEN MS. NEPHROPATHY OF POTASSIUM DEPLETION: REPORT OF A FATAL CASE1. Ann Intern Med. ;53:796–807. doi: 10.7326/0003-4819-53-4-796
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Published: Ann Intern Med. 1960;53(4):796-807.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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