ARTHUR J. SEAMAN, M.D., F.A.C.P.
The coagulation proteins in the peripheral blood are in a state of dynamic equilibrium. All of those synthesized in the liver have a life span ranging from a few hours to a maximum of 14 days. The plasma values at any one moment, then, are the resultant of the rate of synthesis and the rate of degradation in both intra- and extravascular locations of these coagulation factors. The indirect anticoagulants act by inhibiting the rate of synthesis in the liver of the following coagulation proteins: prothrombin (II),3 proconvertin (VII), plasma thromboplastin component (IX), and Stuart factor (X). After the administration
SEAMAN AJ. OWREN'S CAPILLARY BLOOD THROMBOTEST FOR OFFICE OR BEDSIDE CONTROL OF ANTICOAGULANT THERAPY: AN EVALUATION12. Ann Intern Med. 1960;53:914–923. doi: 10.7326/0003-4819-53-5-914
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Published: Ann Intern Med. 1960;53(5):914-923.
Cardiology, Coagulopathies, Education and Training, Hematology/Oncology.
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