SAMI I. SAID, M.D.
In 1955 a clinical "syndrome" was described that consisted of extreme obesity, hypoventilation, arterial hypoxia, polycythemia, and right heart failure.1 Since then the physiologic mechanisms by which obesity could interfere with cardiorespiratory function have been under study.2-17 Most reports have dealt with obese patients showing clinical evidence of dysfunction, and who were, therefore, probably in an advanced stage of the disorder. In an effort to elucidate the sequence of events that ultimately lead to the development in the obese of the so-called "pickwickian syndrome," we set out to study a group of subjects selected solely because of their marked obesity.
SAID SI. ABNORMALITIES OF PULMONARY GAS EXCHANGE IN OBESITY12. Ann Intern Med. 1960;53:1121–1129. doi: 10.7326/0003-4819-53-6-1121
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Published: Ann Intern Med. 1960;53(6):1121-1129.
Obesity, Pulmonary/Critical Care.
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