VICTOR E. CHVOJKA, M.D.
Pancreatic endocrine function has long been suspect in gastroduodenal ulceration, although it has never been definitely and conclusively incriminated. The existence of an intrinsic factor of the pancreas that is not related to its external secretions but that may be active in peptic ulcerogenesis was postulated by Poth in 1948.1 This concept was based on the earlier experimental observations of Dragstedt, Elman, Poth, and others that duodenal ulcers may be produced by deviation of the alkaline secretions of the pancreas by external fistulas or by ligation of the pancreatic ducts. These ulcers had usually been considered to be the result
CHVOJKA VE. ISLET-CELL TUMORS AND PEPTIC ULCERS: CASE REPORT OF THE ZOLLINGER-ELLISON SYNDROME1. Ann Intern Med. ;53:1180–1195. doi: 10.7326/0003-4819-53-6-1180
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Published: Ann Intern Med. 1960;53(6):1180-1195.
Endocrine and Metabolism, Endocrine Cancer, Gastroenterology/Hepatology, Hematology/Oncology, Pancreatic Disease.
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