ROBERT S. ABERNATHY, M.D.; G. THOMAS JANSEN, M.D.
The therapy of North American blastomycosis has not been completely satisfactory in the past. Although the aromatic diamidines, particularly stilbamidine and the less toxic 2-hydroxystilbamidine, have proved to be effective and distinctly more potent than potassium iodide, x-ray, or vaccine therapy, significant numbers of patients have been resistant to therapy, or have experienced recurrences of the disease despite large amounts of the diamidines given over long periods.7, 13 Recent trials of amphotericin B2, 6, 7, 10, 11, 14 have shown that it is an effective therapeutic agent for a variety of deep mycotic infections, including North American blastomycosis. Indeed, in
ABERNATHY RS, JANSEN GT. THERAPY WITH AMPHOTERICIN B IN NORTH AMERICAN BLASTOMYCOSIS1. Ann Intern Med. 1960;53:1196–1203. doi: 10.7326/0003-4819-53-6-1196
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Published: Ann Intern Med. 1960;53(6):1196-1203.
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