CARLETON B. CHAPMAN
The survival and, in a sense, the supremacy of the mammalian class are dependent on biological control mechanisms that render the organism extraordinarily responsive to change. One such control mechanism is that which governs the heart, conferring on it the ability to vary its output and external work between very wide limits in remarkably short periods of time. Some organisms, whose natural environment requires relatively little responsiveness, have no need for complex control systems. Yet no organism high enough in the zoological scale to possess anything resembling a heart is totally unresponsive to change. In no known organism is the
CHAPMAN CB. ON THE NATURE OF CARDIAC CONTROL12. Ann Intern Med. ;53:1272–1280. doi: 10.7326/0003-4819-53-6-1272
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Published: Ann Intern Med. 1960;53(6):1272-1280.
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