W. THOMAS LONDON, M.D.; STANLEY E. ROSENBERG; JOHN W. DRAPER, M.D.; THOMAS P. ALMY, M.D., F.A.C.P.
In the past much of the research concerning atherosclerosis has been directed toward prevention of the disease. Interest has been focused on particular groups, such as premenopausal women (1), Bantus (2), and Okinawans (3), who are relatively free of atherosclerosis presumably because of dietary habits or hormonal status.
Direct evidence of the effectiveness of estrogen has been provided by Pick, Stamler, Rodbard, and Katz (4), who were able by this means to inhibit development of coronary atherosclerosis in cholesterol-fed cockerels.
Of greater clinical importance is the question of whether atheromata, once it is present, can be resolved by therapeutic measures.
LONDON WT, ROSENBERG SE, DRAPER JW, ALMY TP. The Effect of Estrogens on Atherosclerosis: A Post-mortem Study. Ann Intern Med. ;55:63–69. doi: 10.7326/0003-4819-55-1-63
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Published: Ann Intern Med. 1961;55(1):63-69.
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