HENRY A. AZAR, M.D.; CHARLES K. NUCHO, M.D.; SHIBLI I. BAYYUK, B.SC., M.SC.; WARDIH B. BAYYUK, B.SC.
Chronic fluoride intoxication, as manifested by mottling of tooth enamel and diffuse osteosclerosis, has been observed throughout the world in communities in which the domestic water supply contained fluoride in concentrations usually in excess of four parts per million (1-5). On the other hand, a series of well-coordinated investigations in the United States has supported the concept that no clinically significant, adverse, physiological, or functional effects, with the exception of dental fluorosis, are to be anticipated in persons whose water supply contains fluoride in the concentration of 8 ppm (6). In a recent review of approximately 170,000 roentgenologic examinations of
AZAR HA, NUCHO CK, BAYYUK SI, BAYYUK WB. Skeletal Sclerosis Due to Chronic Fluoride Intoxication: Cases from an Endemic Area of Fluorosis in the Region of the Persian Gulf. Ann Intern Med. ;55:193–200. doi: 10.7326/0003-4819-55-2-193
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Published: Ann Intern Med. 1961;55(2):193-200.
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