J. R. E.
Despite the dramatic advances in cardiac surgery and the development of ever more potent diuretic drugs, the patient with heart disease and edema continues to pose a very real physiologic and therapeutic problem. The pathogenesis of congestive heart failure is still obscure although edema has been recognized for a long time to be an abnormal accumulation in various parts of the body of water, sodium, and other extracellular electrolytes. The causal chain of events that leads to this accumulation has been the goal of a host of investigators whose paths have led through many a jungle of hemodynamic, endocrinologic, and
J. R. E.. Water, Salt, and the Failing Heart. Ann Intern Med. 1961;55:532–536. doi: 10.7326/0003-4819-55-3-532
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Published: Ann Intern Med. 1961;55(3):532-536.
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