KENDALL A. ELSOM, M.D., F.A.C.P.; GILBERT W. BEEBE, PH.D.; JOHN J. SAYEN, M.D., F.A.C.P.; HAROLD G. SCHEIE, M.D.; GEORGE D. GAMMON, M.D., F.A.C.P.; FRANCIS C. WOOD, M.D., F.A.C.P.
Scrub typhus is an acute febrile illness caused by Rickettsia tsutsugamushi. It occurs widely throughout the southern Pacific islands and in southern Asia, especially in the southwest Pacific and in southeast Asia. The causative agent is transmitted by the bite of an infected mite. The disease is characterized by an eschar at the site of entrance of the infecting agent, an early generalized skin rash and, if unmodified by therapy, a prolonged high fever and evidence of widespread tissue damage. The most serious manifestations are myocarditis, meningoencephalitis, and pneumonitis. The untreated disease runs an acute and often severe course, with
ELSOM KA, BEEBE GW, SAYEN JJ, SCHEIE HG, GAMMON GD, WOOD FC. Scrub Typhus: A Follow-up Study. Ann Intern Med. ;55:784–795. doi: 10.7326/0003-4819-55-5-784
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Published: Ann Intern Med. 1961;55(5):784-795.
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