J. M. WALSHE
The nature of the relationship between the liver and the brain is one of the oldest problems in medicine and one that has proved a fruitful source of speculation from the time of Hippocrates to the present day. Space does not permit an historical review of the extensive literature on this subject, nor does the situation require it. It is only in recent years that theory has been replaced by knowledge based on the scientific study of disease. Until scarcely two decades ago the question which bedeviled most writers was the nature and locus of the primary abnormality: Should this
WALSHE JM. The Liver and the Brain. Ann Intern Med. ;55:867–872. doi: 10.7326/0003-4819-55-5-867
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Published: Ann Intern Med. 1961;55(5):867-872.
Gastroenterology/Hepatology, Liver Disease, Neurology.
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