ANN A. BROWDER, M.D.; JOHN W. HUFF, M.D.; ROBERT G. PETERSDORF, M.D.
Fever is often a manifestation of neoplastic disease, and the literature is replete with case reports of patients who were febrile for months and even years before exhaustive investigation revealed a cryptic neoplasm. Hypernephroma is the prototype of tumor frequently associated with fever and is described in several series of patients with fever of unknown etiology (1-3). Actually, however, fever is a relatively rare symptom of renal cell carcinoma. Israel (4) reported that only 8.2% of 146 patients with hypernephroma were febrile, and Soloway (5) noted pyrexia in eight among his 130 patients. Among 273 patients with renal neoplasms reported
BROWDER AA, HUFF JW, PETERSDORF RG. The Significance of Fever in Neoplastic Disease. Ann Intern Med. ;55:932–942. doi: 10.7326/0003-4819-55-6-932
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Published: Ann Intern Med. 1961;55(6):932-942.
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