R. A. BOHANNON, M.D.; J. L. HUTCHISON, M.D., F.R.C.P. (C); S. R. TOWNSEND, M.D., F.A.C.P.
The increasing use of radioisotopes in clinical medicine offers better means of understanding and quantitating physiological processes. Tracer techniques using isotopes of iron allow investigation of iron metabolism and erythropoietic function. Radioiron binds to transferrin, an alpha-1 globulin, which has the capacity of accepting two atoms of iron per molecule of protein. During its transport in the plasma, iron is removed from the plasma at an exponential rate into the bone marrow where it is soon utilized in hemoglobin synthesis. Normally only a small portion of iron leaves the plasma for storage. Subsequently, the tracer reappears in the peripheral circulation
BOHANNON RA, HUTCHISON JL, TOWNSEND SR. The Use of Radioiron in the Study of Anemia. Ann Intern Med. ;55:975–988. doi: 10.7326/0003-4819-55-6-975
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Published: Ann Intern Med. 1961;55(6):975-988.
Hematology/Oncology, Red Cell Disorders.
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