JAMES T. CASSIDY, M.D.
Generalized Amyloidosis is an uncommon disorder; the approximate frequency at autopsy is 0.5%. It is, however, a subject of frequent diagnostic consideration because of its diversified clinical manifestations. The heart is affected to a significant degree in 40 to 90% of cases (1-4). Such involvement was responsible for major disability in two patients, one with primary amyloidosis, the other with amyloidosis secondary to plasmacytoma. Observations in these cases which might suggest amyloid infiltration as a cause for obscure heart disease are discussed, with particular attention to a previously unreported sensitivity to digitalis.
A 58-year-old farmer was
CASSIDY JT. Cardiac Amyloidosis: Two Cases with Digitalis Sensitivity. Ann Intern Med. ;55:989–994. doi: 10.7326/0003-4819-55-6-989
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Published: Ann Intern Med. 1961;55(6):989-994.
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