SHERMAN M. MELLINKOFF, M.D., F.A.C.P.; RICHARD W. SNODGRASS, M.D.; ARTHUR D. SCHWABE, M.D.; JAMES F. MEAD, PH.D.; HENRY E. WEIMER, PH.D.; MARJORIE FRANKLAND, A.B.
Clinical and laboratory features of familial Mediterranean fever have been described by many authors (1-5). A comprehensive and thoughtful analysis of the medical problem and clarification of terminology in the world-wide literature were provided in 1958 by Heller, Sohar, and Sherf (1), stimulating renewed interest in this disease.
In brief, the patients are almost always of Mediterranean ancestry and inherit a tendency to suffer from recurrent short attacks of fever, usually accompanied by peritonitis, pleuritis, arthritis, or dermatitis (6). Ultimately a large number develop amyloidosis, which is apparently not well correlated with the duration or frequency of the febrile episodes
MELLINKOFF SM, SNODGRASS RW, SCHWABE AD, MEAD JF, WEIMER HE, FRANKLAND M. Familial Mediterranean Fever: Plasma Protein Abnormalities, Low-fat Diet, and Possible Implications in Pathogenesis. Ann Intern Med. ;56:171–182. doi: 10.7326/0003-4819-56-2-171
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Published: Ann Intern Med. 1962;56(2):171-182.
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