NORMAN G. SCHNEEBERG, M.D., F.A.C.P.; ELTON HERMAN, M.D.; HYMAN MENDUKE, PH.D.; NORMAN K. ALTSCHULER, M.SC.
It is well known that thyroid hormones can effect a decline in the level of serum cholesterol (1). The dose required, however, usually causes calorigenic stimulation and an increase in myocardial metabolism, side effects which may be disturbing to subjects free of cardiac disease, and not without danger to patients who have coronary heart disease. Numerous thyroxine analogues have been studied in the hope of finding one whose cholesterol lowering action far exceeds its other hormonal effects. Several reports (2, 3) suggest that dextro-thyroxine (3,5,3′,5′-tetraiodo-D-thyroxine) demonstrates these properties and is the best available analogue at present. Current interest in the
SCHNEEBERG NG, HERMAN E, MENDUKE H, ALTSCHULER NK. Reduction of Serum Cholesterol by Sodium Dextro-thyroxine in Euthyroid Subjects. Ann Intern Med. ;56:265–275. doi: 10.7326/0003-4819-56-2-265
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Published: Ann Intern Med. 1962;56(2):265-275.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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