UFFE SAGILD, M.D.; OLE Z. DALGAARD, M.D.; NIELS TYGSTRUP, M.D.
Several syndromes of constitutional hyperbilirubinemia, caused by deficiencies in the elimination of bilirubin by the liver, have been described (1). Some of these may be diagnosed from their clinical course (2-4), while others can be differentiated only on the basis of laboratory findings. Thus the Gilbert-Meulengracht syndrome (5) [constitutional hepatic dysfunction], the Dubin-Johnson syndrome (6) [chronic idiopathic jaundice], and the Rotor syndrome (7) [chronic familial non-hemolytic jaundice with conjugated bilirubin in the serum] may appear to be identical clinically.
The case presented here demonstrates that pathologic findings considered to be typical of different syndromes may be found in the same
SAGILD U, DALGAARD OZ, TYGSTRUP N. Constitutional Hyperbilirubinemia with Unconjugated Bilirubin in the Serum and Lipochrome-like Pigment Granules in the Liver. Ann Intern Med. 1962;56:308–314. doi: 10.7326/0003-4819-56-2-308
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Published: Ann Intern Med. 1962;56(2):308-314.
Gastroenterology/Hepatology, Liver Disease.
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