ROBERT A. LEVINE, M.D.; MARY ANN PAYNE, M.D., F.A.C.P.; PETER M. BURKHOLDER, M.D.
Although more than a century has passed since Virchow first described amyloidosis (1), investigation of its pathogenesis has been limited by the paucity of pathological material available during the early stages of its development. Hypotheses regarding pathogenesis of amyloidosis have heretofore been derived from morphologic studies, staining reactions, and immunologic techniques performed on specimens of tissue obtained in the end stages of the disorder.
The authors have had the opportunity to perform studies on a series of blood samples and specimens of tissue obtained over a one-year period from a patient with amyloidosis unassociated with a predisposing disease, before the
LEVINE RA, PAYNE MA, BURKHOLDER PM. Asymptomatic Primary Systemic Amyloidosis. Ann Intern Med. ;56:397–408. doi: 10.7326/0003-4819-56-3-397
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Published: Ann Intern Med. 1962;56(3):397-408.
Hospital Medicine, Nephrology.
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