WILLIAM G. SANFORD; JAMES R. RASCH; ROBERT B. STONEHILL
Except in its disseminated form, coccidioidomycosis is a benign pulmonary disorder which is endemic in the southwestern part of the United States. The disseminated or progressive primary form has a fatality rate of more than 50% and requires vigorous, if not heroic, treatment (1). Although amphotericin B is relatively toxic, it has become recognized as the most effective antifungal agent for this disorder. The occurrence of transient azotemia has been reported repeatedly with amphotericin B. However, with relatively low dosages, permanent renal damage has not been reported generally. The experience at the USAF Hospital Lackland with six cases of disseminated
SANFORD WG, RASCH JR, STONEHILL RB. A Therapeutic Dilemma: The Treatment of Disseminated Coccidioidomycosis with Amphotericin B. Ann Intern Med. ;56:553–563. doi: 10.7326/0003-4819-56-4-553
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Published: Ann Intern Med. 1962;56(4):553-563.
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