JAMES C. NIEDERMAN, M.D.; EDWARD C. GILBERT, M.D.; HOWARD M. SPIRO, M.D.
Associations between specific diseases and certain hereditary characteristics are becoming increasingly apparent. In particular, the relationship between blood groups and peptic ulcer disease has been amply documented. In 1954, Aird, Bentall, Mehigan, and Fraser Roberts (1) emphasized the increased incidence of blood group O among adult males with duodenal ulcer; further observations revealed that those patients with duodenal ulcer who subsequently required operation accounted to a large extent for this blood group O excess (2). Clinical studies have demonstrated the additional physiologic importance of secretion of mucopolysaccharide ABH substances into body fluids, especially those of the stomach (3). A significantly
NIEDERMAN JC, GILBERT EC, SPIRO HM. The Relationship between Blood Pepsin Level, ABO Blood Group, and Secretor Status. Ann Intern Med. ;56:564–569. doi: 10.7326/0003-4819-56-4-564
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Published: Ann Intern Med. 1962;56(4):564-569.
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