ROBERT VOLPÉ, M.D., F.R.C.P.(C); MACALLISTER W. JOHNSTON, M.D., F.R.C.P.(C)
The administration of stable iodine to hyperthyroid patients has long been known to produce at least temporary clinical benefit. Iodine was used in the treatment of toxic goiter as early as 1840 by von Basedow (1) and in 1854 by Stokes (2). Although Trousseau (3) disagreed with the earlier enthusiasm, in 1868 he convincingly described the beneficial effect of iodine in hyperthyroidism after he had accidentally prescribed tincture of iodine instead of tincture of digitalis to a hyperthyroid patient. In spite of his success with this case, he continued to look upon iodine as a dangerous drug for this disease.
VOLPÉ R, JOHNSTON MW. The Effect of Small Doses of Stable Iodine in Patients with Hyperthyroidism. Ann Intern Med. ;56:577–589. doi: 10.7326/0003-4819-56-4-577
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Published: Ann Intern Med. 1962;56(4):577-589.
Endocrine and Metabolism, Thyroid Disorders.
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