W. Hollander, M.D. (Assoc.); R. N. Kaplan, M.D.; A. V. Chobenian, M.D.; R. W. Wilkins, M.D., F.A.C.P.
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Since previous studies in this laboratory have indicated that the antihypertensive effect of chlorothiazide is not due exclusively to its diuretic effect, diazoxide, a non-diuretic thiazide, was tested in 28 hypertensive subjects over the past six months. In a daily oral dose of 200 mg, diazoxide produced significant lowerings of blood pressure which ranged from 15/10 to 45/24 mm Hg. The reductions of blood pressure were not orthostatic, but occurred similarly in both the supine and upright positions. They appeared to result from a decrease in peripheral resistance, since cardiac output did not change. Diazoxide given intravenously in a dose
W. Hollander, R. N. Kaplan, A. V. Chobenian, R. W. Wilkins. The Antihypertensive Activity of a Non-diuretic Benzothiadiazine, Diazoxide.. Ann Intern Med. 1962;56:668. doi: 10.7326/0003-4819-56-4-668_1
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Published: Ann Intern Med. 1962;56(4):668.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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