J. J. Leonard, M.D. (Assoc.); F. Kroetz, M.D.; W. J. DeGroot, M.D.; I. Goldstein
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The left ventricle of the intact organism responds to the augmented flow of muscular exercise by increasing the rate of contraction and ejection. Studies with epinephrine infusion and sympathetic nerve stimulation closely mimic this ventricular response to exercise. These similarities suggest that the ventricular adaptation to exercise is controlled by adrenergic activity. To test this hypothesis, the isovolumetric contraction period at rest and exercise was measured before and after ganglionic blockade and sympathetic nerve paralysis.
The duration of left ventricular isovolumetric contraction was determined by subtracting the period of ejection, as measured from the carotid pulse tracing, from the period
Leonard JJ, Kroetz F, DeGroot WJ, Goldstein I. The Effect of Chemical Autonomic Inhibition on the Rate of Left Ventricular Isovolumetric Contraction.. Ann Intern Med. ;56:669. doi: 10.7326/0003-4819-56-4-669_1
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Published: Ann Intern Med. 1962;56(4):669.
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