M. J. Seide, M.D. (Assoc.)
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Since their introduction 20 years ago, coumarin-type drugs have become firmly established in clinical medicine. In the past ten years, the number of patients maintained on long-term therapy has increased phenomenally.
The Quick prothrombin test is widely accepted by clinicians as a guide in determining the dose of coumarin. It is a bio-assay which requires meticulous technique, experienced technicians, and reliable reagents. More than one laboratory may be involved in the care of an individual patient, since treatment usually begins in the hospital during acute illness, then continues on an outpatient basis.
To determine the validity, reproducibility, and reliability of
Seide MJ. Laboratory Control of Coumarin Anticoagulation: The Clinician's Dilemma.. Ann Intern Med. ;56:671. doi: 10.7326/0003-4819-56-4-671_1
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Published: Ann Intern Med. 1962;56(4):671.
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