J. C. Beck, M.D. (Assoc.); E. E. McGarry, M.D. (Assoc.)
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Antibodies to insulin and anterior pituitary hormone preparations from various species have been produced in rabbits. Using the hemagglutination reaction, antisera to growth hormone and follicle-stimulating hormone preparations and human chorionic gonadotrophin were found to be species specific, in contrast to antisera to insulin, adrenocorticotrophic hormone, and thyrotrophin, which did not show species specificity. Hormone specificity of antisera was also demonstrated by the ability to inhibit the biological activity of the respective hormone antigen in vitro. Such experiments with inhibition have also been used to demonstrate the specificity of the biological activity of various hormones. Fluorescein-tagged gamma globulin preparations of
Beck JC, McGarry EE. The Application of Immunochemical Techniques to the Study of Protein Hormones.. Ann Intern Med. ;56:673. doi: 10.7326/0003-4819-56-4-673_1
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Published: Ann Intern Med. 1962;56(4):673.
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