W. H. Beierwaltes, M.D., F.A.C.P.; E. Linz, A.B.
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Previously, we have reported the occurrence of a two to three-fold increase in the serum protein-bound iodine (PBI) concentration in euthyroid individuals caused by a hereditary increase in the available thyroxine-binding sites in serum alpha globulin.
Two types of systematic studies have now been performed under controlled conditions to rule out a qualitative abnormality in this trace protein as a cause of increased binding of thyroxine. Reverse-flow electrophoresis of radioactive iodine-labelled normal serum and serum from a patient with the hereditary defect were carried out at small increments in pH ranging from 2.5 to 11.5, with appropriate buffers. These experiments
Beierwaltes WH, Linz E. Hereditary Increase in Serum Thyroid Hormone Concentrations.. Ann Intern Med. ;56:673. doi: 10.7326/0003-4819-56-4-673_2
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Published: Ann Intern Med. 1962;56(4):673.
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