S. H. Ingbar, M.D.
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Following its release from the thyroid gland, thyroxine enters into a reversible binding equilibrium with specific plasma proteins. As a result of these interactions, only a small proportion of the hormone remains free or unbound, while the remainder acquires macromolecular characteristics which profoundly influence its subsequent metabolism. Evidence indicates that it is the unbound hormone which is available to tissues for metabolic action, degradation, or excretion, while the bound hormone may be metabolically inert. Changes in the protein-hormone interaction, resulting from alterations in the concentration of either thyroxine or its binding sites, alter the proportion of the unbound thyroxine and
Ingbar SH. Thyroid Hormone Transport and Utilization.. Ann Intern Med. ;56:675. doi: 10.7326/0003-4819-56-4-675_2
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Published: Ann Intern Med. 1962;56(4):675.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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