L. J. Marks, M.D. (Assoc.)
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Adrenocortical function was studied in 44 patients with carcinoma of the lung by measuring their plasma 17-hydroxycorticosteroid response to adrenocorticotrophic hormone. Although Cushing's syndrome was not present in any of these subjects, 36% demonstrated an exaggerated plasma corticosteroid response to ACTH. The results of the adrenal function studies could be correlated better with the severity of the patient's clinical illness than with either a specific cell type of lung cancer or the alterations in the adrenals observed at autopsy. Bio-assays of the pituitary glands for ACTH were performed for seven cases who died from lung cancer, using hypophysectomized rats. The
Marks LJ. Adrenocortical Function in Carcinoma of the Lung with and without Cushing's Syndrome.. Ann Intern Med. ;56:677. doi: 10.7326/0003-4819-56-4-677_1
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Published: Ann Intern Med. 1962;56(4):677.
Adrenal Disorders, Endocrine and Metabolism, Hematology/Oncology, Lung Cancer, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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