N. J. Nadler, M.D., Ph.D.
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The thyroid gland is made up of individual follicles in each of which there is a single layer of epithelial cells surrounding a lumen. In the lumen is contained the so-called colloid which is composed predominantly of a mucoprotein, thyroglobulin. Within the framework of this thyroglobulin molecule, the synthesis of thyroid hormones, thyroxine and triiodothyronine, takes place.
Since leucine is a prominent amino acid of thyroglobulin, it has been possible to trace the synthesis of thyroglobulin in follicles by means of radioautographs prepared from fixed histological sections of thyroid glands obtained at various times after the administration of leucine labelled
Nadler NJ. Synthesis of Thyroid Hormone.. Ann Intern Med. ;56:677. doi: 10.7326/0003-4819-56-4-677_2
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Published: Ann Intern Med. 1962;56(4):677.
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