J. R. Senior, M.D.; K. J. Isselbacher, M.D.
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Recently developed techniques have permitted analysis of the steps in the breakdown of ingested dietary lipids, absorption of the products thereof into the intestinal mucosal cells, re-synthesis of specific new lipids within the cell, and formation of chylomicrons which enter the lymph. Methods of isolation of the gut epithelial cells and their fractionation into subcellular organelles have been worked out. Using these methods, as well as separation and identification of isotopically-labeled lipids on silicic acid columns and thin layers, it has been possible to localize within the cells the sites of several of the sequential steps. An enzyme has been
Senior JR, Isselbacher KJ. Pathways of Intestinal Fat Absorption.. Ann Intern Med. ;56:680. doi: 10.7326/0003-4819-56-4-680_2
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Published: Ann Intern Med. 1962;56(4):680.
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