M. J. Cline, M.D.; N. I. Berlin, M.D.
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The pathogenetic mechanisms of anemia in 11 patients with chronic myelocytic leukemia were studied using radioactive iron to measure the rate of erythropoiesis and patterns of ferro-kinetics, glycine-2-C14 and diisopropylfluorophosphate-P32 to measure red cell survival, and radioactive sodium chromate to measure total red cell volume, apparent red cell survival, and fecal blood loss.
Six of the patients had normal total red cell volumes despite a low peripheral hemoglobin concentration; this discrepancy probably reflects an increased splenic erythrocyte content.
Evidence for iron deficiency was found in six of the patients. Seven patients had increased plasma cell iron turnover rates as a
Cline MJ, Berlin NI. The Spectrum of Pathogenetic Mechanisms of Anemia in Patients with Chronic Myelocytic Leukemia.. Ann Intern Med. ;56:684. doi: 10.7326/0003-4819-56-4-684_2
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Published: Ann Intern Med. 1962;56(4):684.
Hematology/Oncology, Leukemia/Lymphoma, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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