A. J. Erslev, M.D.
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Recent studies have suggested the existence of a feedback mechanism between the kidney and the bone marrow. The bone marrow, by regulating the size of the red cell mass, is instrumental in maintaining an optimal tissue tension of oxygen in all organs including the kidney. The kidney in turn is believed to respond to the level of its tissue tension of oxygen by releasing an appropriate amount of erythropoietin, a hormone capable of adjusting the rate of red cell production in the bone marrow. Most clinical and experimental observations on the dynamics of anemia and polycythemia are compatible with the
Erslev AJ. Renal and Extrarenal Control of Red Cell Production.. Ann Intern Med. ;56:685. doi: 10.7326/0003-4819-56-4-685_1
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Published: Ann Intern Med. 1962;56(4):685.
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