R. D. Lange, M.D., F.A.C.P.; N. I. Gallagher, M.D.
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The kidney has been linked to erythropoiesis by both clinical and experimental investigations. Our studies of this association are reported, and the significance of these findings in the pathogenesis of renal anemia and polycythemia is discussed.
Jacobson and co-workers have postulated, from animal organ extirpation experiments, that the kidney is the source or "activator" of erythropoietin. Other studies, including our own, demonstrate that the kidney of the rabbit, at least, is not the sole source of erythropoietin. Thus, assays of plasma from nephrectomized rabbits produced a radioactive iron-RBC incorporation of 5 ± 0.3% in assayed animals, while plasma from nephrectomized
Lange RD, Gallagher NI. The Kidney and Erythropoiesis.. Ann Intern Med. 1962;56:685–686. doi: 10.7326/0003-4819-56-4-685_4
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Published: Ann Intern Med. 1962;56(4):685-686.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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