H. N. Eisen, M.D.
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Antigenic determinants are those parts of antigen molecules which are critically involved in the binding of antigens by antibodies. They are, therefore, the segments of antigens which determine specificity of allergic reactions. The definition of antigenic determinants is illustrated with the 2,4-dinitrophenyl group as a model system. Penicillin allergy in man obeys the same general principles observed in the dinitrophenyl system. The determinants of penicillin allergy in man are defined. Reagents which incorporate these determinants have been prepared and used to skin test about 1,500 human subjects. The results are in good agreement with previous histories of penicillin allergy and
Eisen HN. Antigenic Determinants of Hypersensitivity Reactions.. Ann Intern Med. ;56:687. doi: 10.7326/0003-4819-56-4-687_1
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Published: Ann Intern Med. 1962;56(4):687.
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