L. A. Herzenberg, Ph.D.
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The rejection of grafts between genetically different individuals has been clearly shown to be due to an immunological response of the host to the grafted tissue. The specific constituents to which this immune response is directed are the histocompatibility or transplantation antigens.
In the mouse, where the existence of genetically homogeneous (highly inbred) strains allows genetic tests to be performed with facility, several independent determinations have shown that at least 15 separate genetic loci control the formation of as many different histocompatibility antigens. One of these, the H-2 locus, plays a pre-eminent role in graft rejection. Others are much weaker
Herzenberg LA. Histocompatibility Antigens and Tissue Transplantation.. Ann Intern Med. 1962;56:688. doi: 10.7326/0003-4819-56-4-688_1
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Published: Ann Intern Med. 1962;56(4):688.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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