A. Solomon, M.D.; J. L. Fahey, M.D.
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A marked increase in serum viscosity may be responsible for many of the disease manifestations of pathologic states associated with elevated serum macroglobulin levels. For this reason, rational therapy was directed at reduction of serum viscosity and macroglobulin level.
Schwab and Fahey (New Engl. J. Med. 263: 574, 1960) have reported the beneficial effect of plasmapheresis in two patients with Waldenström's macroglobulinemia. Current evaluation of the therapeutic usefulness of plasmapheresis is based on observations in ten patients with macroglobulinemia. Many disease manifestations including bleeding diathesis, visual disturbance and retinal hemorrhages, vertigo and other neurological symptoms, and cardiac limitations were reversed
Solomon A, Fahey JL. Plasmapheresis Therapy in Macroglobulinemia.. Ann Intern Med. ;56:690–691. doi: 10.7326/0003-4819-56-4-690_4
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Published: Ann Intern Med. 1962;56(4):690-691.
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