J. Stokes Jr., M.D.
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The use of passive immunization provided by transplacental antibodies to provide a base for active immunization by living viruses, thus producing infection without symptoms plus solid immunity, was demonstrated most effectively by Fenner in mouse-pox. At the same time it was also demonstrated by our group that exposure of persons to hepatitis virus under epidemic conditions following their passive immunization by various dosages of gamma globulin prepared by ethanol fractionation was highly effective in producing an active immunity of long and perhaps permanent duration. The use of antibodies plus active virus had been studied in the past for immunization in
Stokes J. The Use of Passive Immunization in Certain Viral Diseases. The James D. Bruce Memorial Lecture.. Ann Intern Med. 1962;56:691. doi: 10.7326/0003-4819-56-4-691_3
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Published: Ann Intern Med. 1962;56(4):691.
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