J. H. Vaughan, M.D., F.A.C.P.; R. T. Schwartz, M.D.
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Observations in patients have repeatedly indicated that man may develop an immunological response to penicillin that can cause hypersensitivity symptoms. During recent years we have been interested in studying the type of immunological response being made by patients treated with penicillin in relation to whether or not symptoms of hypersensitivity develop.
Nineteen of 23 patients with anaphylaxis, urticaria, or "serum sickness" following penicillin were found to have serum antibody detectable by agglutination of "penicillinized" red blood cells. This antibody was more commonly 19S (molecular weight around 1 million) in sedimentation characteristics, but 7S (molecular weight around 160,000) antipenicillin antibody also
Vaughan JH, Schwartz RT. Immunological Responsiveness of Man to Penicillin.. Ann Intern Med. ;56:692. doi: 10.7326/0003-4819-56-4-692_2
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Published: Ann Intern Med. 1962;56(4):692.
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