B. Gardner, M.D.
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Participation in the National Cooperative Study of the effect of experimental steroids on advanced breast cancer required classification of sites of metastases (osseous or soft tissue) and evaluation of activity (objective regression, progression, or static) in each patient at four to six-week intervals. Regression was defined as:  significant shrinkage of measurable lesions,  calcification of osseous metastases,  failure of new lesions to appear, and  confirmation by two disinterested experts. Simultaneous measurement of serum and urinary calcium levels permitted correlation with clinical status.
Although hypercalcemia occurred more commonly in association with osseous disease, it also was found in
Gardner B. Calcium and Phosphorus Metabolism in Breast Cancer.. Ann Intern Med. ;56:693–694. doi: 10.7326/0003-4819-56-4-693_3
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Published: Ann Intern Med. 1962;56(4):693-694.
Breast Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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