J. F. Morrissey, M.D.; M. Ochoa, M.D.; W. D. Lotspeich, M.D.; C. Waterhouse, M.D., F.A.C.P.
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Recently it has been proposed that in renal tubular acidosis the limited renal excretion of hydrogen ion against a concentration gradient might be due to a quantitative defect in energy production from the Kreb's cycle within the renal tubular cell. Several observations, including our own, have confirmed the finding of low urinary citrate in renal tubular acidosis. Since citrate is an important component of the Kreb's cycle, it seemed pertinent to measure its excretion in this disease under varying conditions. In an adult with well-documented renal tubular acidosis, studied on the metabolism ward, control values for urinary citrate were 10
Morrissey JF, Ochoa M, Lotspeich WD, Waterhouse C. Citrate Excretion in Renal Tubular Acidosis.. Ann Intern Med. ;56:697–698. doi: 10.7326/0003-4819-56-4-697_4
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Published: Ann Intern Med. 1962;56(4):697-698.
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