M. E. Shils, M.D., SC.D.
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Since the introduction of tetracycline antibiotics into clinical medicine, sporadic reports have appeared in which a proportion of patients receiving this type of drug have developed increases of varying degree in the blood urea nitrogen or non-protein nitrogen. Some insight into the cause of the azotemia was afforded by the metabolic studies of Gabuzda and colleagues (Arch. Intern. Med. 101: 476, 1958) who noted significant increases in urinary nitrogen in malnourished subjects given various tetracyclines. This observation has been confirmed by Faloon and co-workers and by ourselves.
Because of dependence on the kidney for elimination of this group of antibiotics,
Shils ME. Renal Disease and the Metabolic Effects of Tetracycline.. Ann Intern Med. ;56:698. doi: 10.7326/0003-4819-56-4-698_1
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Published: Ann Intern Med. 1962;56(4):698.
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